Genomic Medicine: A Decade of Successes, Challenges, and Opportunities
“Today, we are on a path toward implementation of genomic medicine, but that path is long, mired with obstacles, and potentially perilousHow will ...

Genomic medicine promises to radically alter healthcare. By understanding the predictive power of patients' genomes and the products of those genomes, it should be possible to identify individuals at risk of disease and to create smarter, more effective treatments for those who are already ill.
The IGSP's research in genomic medicine is dedicated to making that happen. The strategy is to bring together programs, initiatives and experts working in various areas of medicine – from cardiovascular and infectious disease to cancer and primary care – all dedicated to translating genomic information into practical tools designed to inform clinical decision making and medical practice. It is our overarching aim to open up a pipeline of progress, allowing genomic advances to flow from discovery to translation to implementation.
As a foundational element, the IGSP has created a multi-disciplinary Clinical Genomics Studies Unit (CGSU) to design and execute genome-inspired clinical trials. We also rely on The Duke IGSP Biospecimen Repository, a standardized, regulatory compliant and privacy protected repository for fluid and tissue specimens and a newly designated Point of Care Molecular Diagnostics Development Laboratory that is a joint effort of the IGSP and the Pratt School of Engineering.
“Today, we are on a path toward implementation of genomic medicine, but that path is long, mired with obstacles, and potentially perilousHow will ...
Professor Patrick Tan described how he has used exome sequencing to investigate the molecular mechanisms underlying various cancers endemic to Asia.
Nicholas Katsanis says studying genetic disease once it’s either killed a patient or been fully expressed is like archaeology: “We go in after the massacre has occurred, we dust ...
Using a novel genetic ‘editing’ technique, Duke University biomedical engineers have been able to repair a defect responsible for one of the most common inherited disorders, ...
Geoff Ginsburg is a collaborator on a study introducing a new constrained model and the corresponding algorithm to identify biological signatures from high-dimensional assays like gene ...
Art Moseley and colleagues present a proof-of-concept study demonstrating the complementary nature of proteomic and genomic techniques for investigating airway (patho)physiology.
Ashley Chi and colleagues report a novel iron-responsive mechanism for the post-transcriptional regulation of ferroportin, mediated by miR-485-3p, which is induced during iron ...
Geoff Ginsburg is an author of a report aimed to engage the scientific community in providing a vision for cancer epidemiology in the 21st century.
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