Error Correction in Gene Synthesis Technology
2011 December 28
In Trends in Biotechnology, Jingdong Tian and colleagues discuss new trends and promising strategies of error filtration, correction and prevention in de novo gene and genome synthesis.
IGSP Publications
The Latest Genome ResearchDecember 2011 Publications
Evolution of Networks and Sequences in Eukaryotic Cell Cycle Control
2011 December 27
In Philosophical Transactions of the Royal Society of London, Nick Buchler and colleagues write that the presence in plants of cell cycle regulators such as Rb, E2F and cyclins A and D, which appear lost in yeast, suggests cell cycle control in the last common ancestor of the eukaryotes was implemented with this set of regulatory proteins.
Curated Collection of Yeast Transcription Factor DNA Binding Specificity Data Reveals Novel Structural and Gene Regulatory Insights
2011 December 21
In Genome Biology, Raluca Gordân and colleagues analyze in vitro and in vivo transcription factor-DNA binding data reported in previous large-scale studies to generate a comprehensive, curated resource for S. cerevisiae.
A Densely Interconnected Genome-Wide Network of MicroRNAs and Oncogenic Pathways Revealed Using Gene Expression Signatures
2011 December 15
In PLoS Genetics, Patrick Tan and colleagues in Singapore conclude that gene expression signatures can be used as surrogates of miRNA activity.
A Genome-Wide Analysis of Open Chromatin in Human Tracheal Epithelial Cells Reveals Novel Candidate Regulatory Elements for Lung Function
2011 December 14
Greg Crawford is a collaborator on a study in the journal Thorax using DNase I hypersensitivity mapping followed by deep sequencing to generate a map of open chromatin in primary human tracheal epithelial cells.
Reduced Selective Constraint in Endosymbionts: Elevation in Radical Amino Acid Replacements Occurs Genome-Wide
2011 December 14
In this PLoS One report, Jennifer Wernegreen tests the hypothesis that purifying selection against radical amino acid changes is less effective in two insect endosymbiont groups than in related bacteria.
Changes in Gene Expression Associated with Reproductive Maturation in Wild Female Baboons
2011 December 08
In Genome Biology and Evolution, Courtney Babbitt, Jenny Tung, Greg Wray and Susan Alberts suggest that adaptive change in the development of the primate ovary may be largely driven at the mechanistic level by selection on gene regulation.
Erythrocyte Plasma Membrane-Bound ERK1/2 Activation Promotes ICAM-4-Mediated Sickle Red Cell Adhesion to Endothelium
2011 December 06
Arthur Moseley is a collaborator on a report in Blood exploring the mechanism underlying adhesion of sickled red blood cells to the endothelium of blood vessels.
Functional Interaction Between Responses to Lactic Acidosis and Hypoxia Regulates Genomic Transcriptional Outputs
2011 December 01
Xiaohu Tang, Joe Lucas and Ashley Chi have published a study in Cancer Research showing that a significant portion of the transcriptional response to hypoxia elicited in cancer cells is abolished by simultaneous exposure to lactic acidosis.
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