"The stakes are high, because present uncertainty over the existence and extent of patent rights casts a shadow over those making decisions about clinical and other applications of gene patents," writes Bob Cook-Deegan in Science.
In The Pharmacogenomics Journal, Susanne Haga and colleagues find differing interests in pharmacogenomic testing among US adults and recommend that providers clearly discuss with their patients the purpose of testing, alternative testing options and policies to protect patient privacy and confidentiality.
In the Journal of Law, Medicine & Ethics, Britt Rusert of Temple University and the IGSP's Charmaine Royal shows how the drugmaker, NitroMed, used the support it had solicited from black advocacy groups and community members to market BiDil as a unique "grassroots" pharmaceutical to the African American community.
The potential of the human genome "to enlighten us about ourselves, our relationship to one another, and our place in the scheme of life makes it a distinctive reservoir for ground-breaking science and personal reflection," writes Charmaine Royal in Science.
In the Journal of General Internal Medicine, Susanne Haga, Lori Orlando, Geoff Ginsburg and Alex Cho report survey results showing that familiarity with genomic testing is a key predictor of physician ordering behavior.
In Nature Protocols, Jiayuan Quan and Jingdong Tian describes a sequence-independent approach for cloning complex individual or combinatorial DNA libraries, and for routine or high-throughput cloning of single or multiple DNA fragments.
In Molecular Ecology, Jenny Tung, Susan Alberts and Greg Wray report results illustrating how environmental and ecological data can be integrated into evolutionary genetic studies of functional variation in natural populations.
In Cold Spring Harbor Protocols, Petra Roulhac, Erich Jarvis and Art Moseley describe a microproteomic platform that uses nanoscale liquid chromatography/tandem mass spectrometry to simultaneously identify and quantify hundreds of proteins from laser capture microdissections of tissue from samples containing as few as 1,000 cells.
In Proceedings of the National Academy of Sciences, Paul Magwene and colleagues provide new insights into the roles that both outcrossing and mitotic recombination play in shaping the genome architecture of the yeast S. cerevisiae.
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