April 2010 Publications
2010 April 29
In PLoS Genetics, Jeanette McCarthy, Geoff Ginsburg and colleagues report that genetic polymorphisms may contribute to inter-individual variation in the activity and mass of Lp-PLA(2), an enzyme that is an emerging risk factor and therapeutic target for cardiovascular disease.
2010 April 23
In a Genome Research commentary, Laura Beskow and colleagues highlight the complexities in genotype-driven research recruitment, in which study participants are recontacted about follow-up studies involving in-depth phenotyping to understand the relationship between observable traits and the gene variant of interest.
2010 April 21
Philip Benfey and colleagues show in Nature that developmental patterning in plant roots occurs through crosstalk between the vascular cylinder and the surrounding endodermis mediated by cell-to-cell movement of a transcription factor in one direction and microRNAs in another.
2010 April 20
In a Genome Biology research highlight, Tom Mitchell-Olds says two recent studies in Arabidopsis have identified quantitative trait loci, providing further data on the genetic architecture of complex-trait variation in plants.
2010 April 15
In Development, Philip Benfey and Wolfgang Busch say, "As plants have neither specialized sensory organs nor a nervous system, intercellular regulators are essential for their development."
2010 April 09
In Science, a team including Greg Crawford, Terry Furey, Vishwanath Iyer and Ewan Birney report evidence that heritable chromatin status and transcription factor binding differ on the basis of genetic variation and may underlie phenotypic variation in humans, including differences in disease risk. The study was covered by The Scientist and New Scientist.
2010 April 05
Mike Datto and colleagues conclude in the Journal of Clinical Oncology that intratumor heterogeneity, although present at the level of individual gene expression, does not preclude precise microarray-based predictions of tumor behavior or clinical outcome in breast cancer patients.